Predictive Environmental Risk Assessment of Chemical Mixtures : A Conceptual Framework
Mis à jour le | Commissariat général au développement durable
Partager la page
Environmental risks of chemicals are still often assessed substance-by-substance, neglecting mixture effects. This may result in risk underestimations, as the typical exposure is toward multicomponent chemical “cocktails”. We use the two well established mixture toxicity concepts (Concentration Addition (CA) and Independent Action (IA)) for providing a tiered outline for environmental hazard and risk assessments of mixtures, focusing on general industrial chemicals and assuming that the “base set” of data (EC50s for algae, crustaceans, fish) is available. As mixture toxicities higher than predicted by CA are rare findings, we suggest applying CA as a precautious first tier, irrespective of the modes/mechanisms of action of the mixture components. In particular, we prove that summing up PEC/PNEC ratios might serve as a justifiable CA-approximation, in order to estimate in a first tier assessment whether there is a potential risk for an exposed ecosystem if only base-set data are available. This makes optimum use of existing single substance assessments as more demanding mixture investigations are requested only if there are first indications of an environmental risk. Finally we suggest to call for mode-of-action driven analyses only if error estimations indicate the possibility for substantial differences between CA- and IA-based assessments.
/BOUCLE_condition_pdf>
Ouvrir l'horizon
- Chiffres clés du climat – France, Europe et Monde – Édition 2023
- Sports de nature : préservez l’environnement en partageant vos itinéraires !
- Notre alimentation, c’est combien de gaz à effet de serre (GES) ?
- Limites planétaires
- Nouvelles maladies infectieuses : quels liens avec les atteintes à la biodiversité ?
- Terres rares, aimants permanents : comment pourvoir aux besoins pour réussir la transition énergétique ?
- Comment économiser efficacement l’eau et l’énergie chez soi ?
- Changement climatique : une plateforme de Météo France pour se projeter en 2050
- Comment jardiner en préservant la biodiversité ?
- Mobilité : quelles aides en 2023 pour réduire nos émissions de CO2 ?
- Comment réussir son compost ?
- Une appli pour suivre les indicateurs du développement durable de son territoire